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How to avoid a false negative when using an at-home COVID-19 test

A bottle of drops, a disposable swab in a wrapper, and a paper testing card for a COVID-19 test.
Christopher Connelly
/
四虎影院
A rapid COVID-19 test manufactured by Abbott.

At-home COVID-19 tests are quick, easy and convenient, but sometimes they can give a false negative result. Here are a few tips from an expert on how to get the most accurate results.

As the omicron variant of the coronavirus continues to spread, more people are using at-home, rapid antigen tests to determine whether it鈥檚 safe to interact with people without spreading the virus.

These antigen tests are pretty accurate 鈥 but false negatives, or results that say you don鈥檛 have COVID when you do, can still happen.

Dr. Jaquelin Dudley, a molecular biology professor and associate director of the LaMontagne Center for Infectious Disease at the University of Texas, said many of those false negatives can be chalked up to user error and bad timing.

She said when going to a county-run testing site or pharmacy, trained professionals are taking your samples and can provide guidance 鈥 like asking people to not eat or drink 30 minutes before a saliva sample is taken.

鈥淏ut at home, of course, nobody has control over whether people are following the instructions,鈥 Dudley said.

She stressed the importance of carefully reading and following the directions on the at-home test. The Centers for Disease Control and Prevention (CDC) also recommend washing your hands, cleaning the surface you鈥檙e placing the test on, and leaving all the equipment in its packaging prior to collecting your sample to improve the accuracy of at-home tests.

Waiting a few days after potential exposure before even taking the test can also help reduce your chances of a false negative. Dudley said it takes a few days for antigen tests to be able to detect COVID.

鈥淪omebody will be exposed, for example, and they may test right away,鈥 she said. 鈥淏ut that doesn't give a chance for the virus to reproduce, and if the virus doesn't reproduce, there won't be any antigens or viral protein there to be detected [by the rapid tests].鈥

鈥淭hat's the key thing, is to catch the virus at the peak and not when your immune system still has it under control and has lowered the levels to below the detection limit,鈥 Dudley said.

She said if you鈥檙e having symptoms consistent with COVID, you should stay home and test as soon as those symptoms occur.

If you鈥檙e asymptomatic but think you鈥檝e been exposed to COVID, you should still stay home but wait two to five days after the possible exposure to take an at-home test. Dudley said that should give the virus enough time to reproduce and be detected by the rapid antigen test. You should still quarantine while you鈥檙e waiting those few days though, she said.

Dudley and the CDC both recommend retesting after a few days as well, to have even more confidence that you won鈥檛 be potentially spreading the virus.

Editor鈥檚 note: A previous version of this story inaccurately described the percentage of false negatives from at-home COVID tests.

Got a tip? Email Rebekah Morr at rmorr@kera.org. You can follow her on Twitter .

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Rebekah Morr is 四虎影院's All Things Considered newscaster and producer. She came to 四虎影院 from NPR headquarters in Washington, D.C., where she worked as a news assistant at Weekend All Things Considered.