San Antonio scientists have uncovered one of the disguises used by SARS-CoV-2 鈥� the virus that causes COVID-19 鈥� to hide from the immune system. They are metal ions that everyone has circulating in their body.
Dr. Yogesh Gupta is an assistant professor of biochemistry and structural biology at and an investigator with its . He said metal ions, like magnesium, manganese, and calcium, are often found in high concentrations in COVID-19 patients who are very sick.
鈥淲hat has been observed in COVID-19 patients is that there is some correlation with the disease severity with the level of metal ions,鈥� Gupta said.
Gupta and his colleagues wanted to know why this might happen, and they discovered that in some patients, the COVID virus uses these metal ions to hide from the immune system.
鈥淪ARS-CoV-2 utilize metal ions to change the structure of its own RNA," Gupta said. "Once the structure is changed, then this RNA looks very similar to the human messenger RNA. Now, the immune cells or immune system cannot really distinguish what is foreign, and what is self. And that is a problem.鈥�
It鈥檚 a problem because if the immune system doesn鈥檛 see an invader, it can鈥檛 fight it. Gupta says this discovery may lead to better treatments for COVID-19.
鈥淣ow we have a better idea of how we can design specific small molecules that can block the activity. And those small molecules could potentially be developed as effective antivirals,鈥� Gupta said.
Not just for COVID-19, Gupta added, but for all coronaviruses.
Gupta is the senior author of the research on metal ions and COVID-19 published June 2 in the journal .
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